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Generic Name: Modafinil

Brand Name: Provigil, Alertec

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Modafinil is used for:

Improving wakefulness in patients with excessive sleepiness associated with narcolepsy or other sleep disorders. It may also be used for other conditions as determined by your doctor. It is in a class of drugs called nootropics.

Modafinil is a wakefulness-promoting agent. Exactly how it works is not known, but it is thought to work by altering the natural chemicals (neurotransmitters) in the brain.

Do not use Modafinil if:

you are allergic to any ingredient in Modafinil

you have a history of developing a rash after taking Modafinil

you have a history of certain heart or heart valve problems (eg, mitral valve prolapse, left ventricular hypertrophy)

you are taking cabazitaxel

Contact your doctor or health care provider right away if any of these apply to you.

Before using Modafinil:

Some medical conditions may interact with Modafinil.

Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have liver problems, kidney problems, heart problems (eg, chest pain, heart blood vessel problems, a recent heart attack), or high blood pressure

if you have a history of mental or mood problems (eg, depression, mania, psychosis), suicidal thoughts or actions, or alcohol or other substance abuse or dependence

if you are taking a monoamine oxidase inhibitor (MAOI) (eg, phenelzine)

Some medicines may interact with Modafinil.

Tell your health care provider if you are taking any other medicines, especially any of the following:

Azole antifungals (eg, ketoconazole, itraconazole) because they may increase the risk of Modafinil’s side effects

Carbamazepine, phenobarbital, prazosin, or rifampin because they may decrease Modafinil’s effectiveness

Amphetamines or other stimulants (eg, methylphenidate), anticoagulants (eg, warfarin), diazepam, hydantoins (eg, phenytoin), propranolol, or certain tricyclic antidepressants (eg, clomipramine, desipramine) because the risk of their side effects may be increased by Modafinil

Axitinib, certain benzodiazepines (eg, midazolam, triazolam), cabazitaxel, cyclosporine, hormonal products (eg, birth control tablets, certain hormone replacements), or ulipristal because their effectiveness may be decreased by Modafinil

How to use Modafinil:

Use Modafinil as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Modafinil by mouth with or without food.

Take Modafinil in the morning unless otherwise directed by your doctor.

If you miss a dose of Modafinil, take it as soon as possible. If you do not remember until late afternoon or evening, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Modafinil.

Important safety information when taking Modafinil:

Modafinil may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Modafinil with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do not drink alcohol while you are using Modafinil.

Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Modafinil; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Do not take more than the recommended dose or take more often than prescribed without check with your doctor.

Modafinil cannot cure sleep disorders and it may not stop all of your sleepiness. Do not change your daily habits without first talking to your doctor. Discuss your level of sleepiness with your doctor at each visit.

Do not use Modafinil in place of getting enough sleep. Follow your doctor’s instructions for good sleep habits and using other treatments.

Serious and sometimes fatal skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis) have been rarely reported with Modafinil.

Contact your doctor right away if you develop a rash; red, swollen, blistered, or peeling skin; or blisters on the inside of the eyes, nose, or mouth.

Hormonal birth control (eg, birth control tablets) may not work as well while you are using Modafinil. To prevent pregnancy, use an extra form of birth control (eg, condoms) while you are taking Modafinil and for 1 month after stopping Modafinil.

Lab tests, including blood pressure and liver function, may be performed while you use Modafinil. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Modafinil with caution in the elderly; they may be more sensitive to its effects.
Modafinil should not be used in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding:

If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Modafinil while you are pregnant. It is not known if Modafinil is found in breast milk. If you are or will be breast-feeding while you use Modafinil, check with your doctor. Discuss any possible risks to your baby.

Some people who use Modafinil for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as dependence or addiction. If you stop taking Modafinil suddenly, you may have withdrawal symptoms. These may include sleepiness.

Discuss any questions or concerns with your doctor or pharmacist.

Possible side effects of Modafinil:
All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; diarrhea; dizziness; headache; nausea; nervousness; stomach upset; stuffy nose; trouble sleeping.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); blisters on the inside of the eyes, nose, or mouth; chest pain; confusion; fast or irregular heartbeat; fever, chills, or sore throat; mental or mood changes (eg, aggression, agitation, anxiety, depression, exaggerated sense of well-being, hallucinations, irritability, nervousness); red, swollen, blistered, or peeling skin; severe or persistent headache; shortness of breath; suicidal thoughts or actions; swelling of the hands, ankles, or feet; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, stomach pain, yellowing of the skin or eyes); unusual bruising or bleeding; unusual tiredness or weakness.

If an overdose of Modafinil is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; anxiety; chest pain; confusion; diarrhea; excitation; fast or slow heartbeat; hallucinations; nausea; restlessness; severe or persistent headache or dizziness; sleeplessness; tremor.

Proper storage of Modafinil:

Store Modafinil at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Modafinil out of the reach of children and away from pets.

General information:

If you have any questions about Modafinil, please talk with your doctor, pharmacist, or other health care provider.

Modafinil is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Modafinil or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you.

This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Modafinil.

It does not include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Modafinil.

This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Modafinil.

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